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Run: Antibiotic Time-Out at 72 Hours Inspection

Review antibiotic therapy at 72 hours to confirm the indication, align treatment with culture results, and identify safe de-escalation or IV-to-PO opportunit...

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Review Context

Verify the review occurred near the 72-hour mark after antibiotic initiation.
The clinical reason for treatment should be clearly documented.
Confirm the active agent(s), dose, route, and frequency are available for review.
Review microbiology, imaging, and other diagnostic data that may affect therapy.

Culture and Susceptibility Review

Determine whether culture data are available at the time of review.
If cultures are positive, confirm the organism and susceptibility profile were reviewed.
Verify the regimen matches the identified pathogen and susceptibility data.
Assess whether negative or contaminant results were used to guide therapy decisions.
Clinical findings, labs, and imaging should support continued treatment if antibiotics are maintained.

Necessity and De-escalation

Confirm the team reassessed whether antimicrobial therapy remains indicated.
Determine whether broad-spectrum therapy can be narrowed based on current information.
If evidence does not support infection, therapy should be stopped or clearly justified.
A target stop date or total duration should be documented when therapy continues.
Confirm recommendations were shared with the prescribing or primary team.

IV-to-PO Conversion Assessment

Assess hemodynamic stability, improving symptoms, and overall clinical trajectory.
Confirm the patient can swallow and absorb oral medications.
Verify an oral agent with suitable spectrum and bioavailability is available.
Indicate whether conversion should be made based on the review.

Documentation and Follow-Up

The 72-hour review should be visible in the medical record.
Include next review timing, lab follow-up, or culture follow-up as needed.
Signature of the reviewer completing the audit.

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