Hazardous Drug Handling (USP 800)

USP 800 daily verification of hazardous drug handling — primary engineering control (BSC/CACI), PPE, surface wipe sampling, and waste segregation.

Primary Engineering Control (BSC/CACI)

• BSC/CACI is present, clean, and designated for hazardous drug use
  Confirm the primary engineering control is the correct device for hazardous drug work and is visibly clean, organized, and dedicated to the task.
• Certification status is current and posted
  Verify the BSC/CACI certification label or record is current per facility policy and available for review.
• Airflow / operational check completed before use
  Confirm required daily operational checks are completed and the device is functioning as expected before hazardous drug handling begins.
• Work surface and interior are free of visible contamination
  Inspect the work area for visible residue, spills, damaged liners, or other contamination that could indicate a deficiency in containment or cleaning.
• Required supplies are staged without obstructing airflow
  Verify only necessary supplies are present and positioned to avoid blocking airflow or compromising containment.

PPE Availability and Use

• Chemo-rated gloves are available and in use
  Confirm appropriate chemotherapy-rated gloves are available at point of use and worn during hazardous drug handling.
• Disposable gown or protective apparel is available and worn correctly
  Verify the required gown or protective apparel is worn, fastened, and provides adequate coverage per facility procedure.
• Eye and face protection is available when splash risk exists
  Confirm eye/face protection is available and used when task conditions create a splash or aerosol exposure risk.
• PPE is donned and doffed in the correct sequence
  Observe or verify the required sequence for putting on and removing PPE to reduce contamination risk.

Surface Wipe Sampling and Decontamination

• Required surface wipe sampling is scheduled and documented
  Confirm the facility’s surface wipe sampling plan is current and the latest sampling event is documented per policy.
• Sampling locations reflect high-risk touch points and work surfaces
  Verify sample locations include representative high-risk areas such as work surfaces, pass-throughs, and other contamination-prone points.
• Out-of-limit or positive findings have documented corrective action
  Confirm any failed wipe sampling results have a documented response, including investigation, cleaning, and follow-up testing as required.

Hazardous Waste Segregation and Disposal

• Hazardous drug waste is segregated from non-hazardous waste
  Confirm hazardous drug waste is not mixed with regular trash, sharps, or non-hazardous pharmaceutical waste.
• Waste containers are labeled, closed, and in good condition
  Verify containers are properly labeled, not overfilled, and maintained to prevent leakage or exposure.
• Waste staging area is secure and compliant with facility procedure
  Confirm hazardous waste is staged in the designated area with access controls and housekeeping conditions that prevent contamination or mix-ups.